"First described in 1900, Klippel-Trenaunay syndrome (KTS) is an extremely rare disease. Affecting blood vessels, bones, and soft tissues, this condition results in three characteristic features: a red birthmark known as a port-wine stain, abnormal bone and soft tissue overgrowth, and venous malformations. The increased size of bone and soft tissue can result in oversized limbs, usually in the lower body and legs. The venous malformations can result in large blood clots."
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